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Rainer Breitling

Prof Rainer Breitling

SULSA Professor of Systems Biology

Faculty of Biomedical and Life Sciences

University of Glasgow

0141 330 7374

r.breitling@bio.gla.ac.uk

Research related to synthetic biology:
I am particularly interested in Synthetic Biology as a form of applied Systems Biology: our computational models predict emergent properties of complex biological systems, which can best be tested in engineered systems created by synthetic biology techniques. We use post-genomic technologies (high-performance metabolomics and transcriptomics) to identify regulatory circuits that activate and regulate metabolite production. These are combined with predictive computational modelling of the cellular circuitry. In addition, we use whole-genome sequencing and genome mining techniques to locate silent gene clusters that could produce unknown metabolite classes. Then we exploit this knowledge to design and engineer new bacterial strains that (over-)produce new types of secondary metabolites in a controlled manner. This work is carried out in collaboration with major biotechnology companies in the field of antibiotics discovery (DSM, Ktedogen).

Keywords and interests: post-genomic data integration (including metabolomics and transcriptomics); dynamic modelling of metabolic and signalling pathways; the prediction of gene functions by large-scale genome analysis

Address:
Faculty of Biomedical and Life Sciences
Joseph Black Building, B3.10
University of Glasgow
Glasgow G12 8QQ